Although Duromine has a good safety profile, it may cause adverse effects like other anorexigenic drugs.

Since Duromine anorexigenic effect is based on inhibition of the appetite control center located in the brain, CNS side effects are most often noted when using this drug.

All psychiatric side effects can be divided into two groups:


They are transient and go away in the first few weeks of the treatment.

Dizziness, mild headache, tremor, insomnia, and restlessness.


They develop extremely rarely. Usually they are preceded by a long bad state of health and abdominal discomfort.

Hallucinations and psychotic episodes, depression, euphoria followed by fatigue.

Frequency and severity of CNS adverse reactions of Duromine may depend on a variety of factors. The most important, which affect development of undesired effects to the greatest extent, can be distinguished among them.

These include:

  • degree of obesity;
  • the patient’s age;
  • accompanying illnesses;
  • the body’s individual characteristics.

Metabolic processes that slow down with age and a degree of obesity the person suffers can delay Duromine excretion from the body. As a result, the drug cumulation may occur that increases the risk of side effects.

Obesity-related diseases usually require separate treatment. Duromine interaction with other drugs may lead to an increase in the therapeutic effect of anorexigenic agent and overstimulation of the central nervous system.

For example, simultaneous use of drugs containing thyroid hormones with Duromine increases alertness, irritability and the likelihood of developing insomnia.

Most unpredictable psychiatric side effects develop due to the patient’s increased sensitivity to the active component of Duromine – Phentermine.

In addition, the likelihood of side effects may depend on the body’s individual characteristics and the patient’s type of nervous system.

However, in most cases, if obese person experiences any psychiatric side effects, this may indicate that:

  • the drug is slowly excreted from the body;
  • the applied dose of Duromine is incorrectly matched;
  • the recommended duration of treatment course is exceeded.

Adjustment of the daily dose and adherence to the dosage regimen of Duromine will help reduce the likelihood of side effects occurrence, as well as will reduce their frequency and intensity.